Chemistry and Biochemistry Contact Us Artificial Intelligence Biotechnology Computer Science Cybersecurity Data Analytics and Visualization Digital Marketing and Media Mathematics Occupational Therapy Physician Assistant Physics Speech-Language Pathology The Department of Chemistry and Biochemistry at ¶¶Òõapp College offers a rigorous program of study that emphasizes traditional chemistry and biochemistry curricula as well as encourages undergraduate students to engage in research with our ¶¶Òõapp members during the academic year and summer. Students interested in a career in chemical engineering may consider the combined engineering program with Columbia University School of Engineering and Applied Science Chemistry, a central science, serves as the basis for understanding the natural and physical sciences. A college graduate with a major in chemistry or biochemistry is prepared for a wide choice of science-related careers. The chemical and pharmaceutical industries provide opportunities for applied chemical and biochemical research Medicine and the health science fields emphasize the biological aspect of advances in chemistry and biochemistry Public service-minded individuals with a solid science education can find their niche in environmental protection agencies, consumer advocacy groups and various government offices. In the field of education, there is a nationwide shortage of science teachers on both the elementary and high school levels. Program Information Mission and Goals Mission Statement The mission of the Department of Chemistry and Biochemistry is to provide our students with a solid foundation in the chemical and biochemical sciences and the skills required for scientific analysis and critical thinking. Upon completing the chemistry or biochemistry major the students will be prepared to attend graduate schools (Ph.D. programs) or professional schools (medical, dental, optometry and others). They will be also ready to study and work at various engineering and academic institutions. The undergraduate Chemistry program aims to prepare students for entry into graduate and professional programs and to become active and engaged members of the chemical scientific community by providing students with traditional chemical education integrated with modern research. Student Learning Goals Understand chemical principles in order to explain the phenomena of the natural world. Apply experimental techniques and chemical principles to investigate and solve problems. Effectively communicate technical and scientific information both verbally and in writing. Generate research ideas and design theoretical and experimental methods to test these ideas with ¶¶Òõapp guidance. Program Requirements Chemistry (BA) Chemistry Major (53 Credits) Chemistry Requirements are available here. Core Required Courses (32 credits) CHE 1045R, General Chemistry I, 3 Credits CHE 1046R, General Chemistry II, 3 Credits CHE 1047L, General Chemistry Lab, 2 Credits CHE 1213R, Organic Chemistry I, 3 Credits CHE 1214R, Organic Chemistry II, 3 Credits CHE 1215L, Organic Chemistry Lab, 2 Credits CHE 1122C, Chemical Analysis, 4 Credits CHE 1415R, Physical Chemistry I, 4 Credits CHE 1416R, Physical Chemistry II, 4 Credits CHE 1222, Advanced Laboratory Techniques, 3 Credits CHE1937/1938 Chemistry Seminar, 1 Credit Other Requirements (18 Credits) MAT 1412R/H, Calculus I, 4 Credits MAT 1413R/H, Calculus II, 4 Credits PHY 1031 R&L, Physics I w/Lab, 5 Credits PHY 1032 R&L, Physics II w/Lab, 5 Credits Electives (1 required, 3 credits minimum) CHE 1124, Forensic Chemistry, 3 Credits CHE 1232C, Medicinal Chemistry, 3 Credits CHEM 1233, Synth. & Character, 3 Credits CHEM 1373C/H Bioinformatics, 3 Credits CHE 1375C, Molecular Biochemistry, 4 Credits CHE/BIO 1376R, Principles of Biochemistry, 3 Credits CHE/BIO 1377L, Biochemistry Laboratory, 2 Credits CHE 1378R, Advanced Biochemistry, 3 Credits CHE 1379C, Metals In Biology, 4 Credits CHE 1415L, Physical Chemistry Lab, 3 Credits CHE 1607, Inorganic & Structural, 3 Credits CHE 1611, Mol. Structure & Dynamics, 3 Credits Recommended Courses BIO 1011R&L, Biological Principles I w/Lab, 5 Credits BIO 1012R&L, Biological Principles II w/Lab, 5 Credits CHE 4911, Guided Research, 1-3 Credits Biochemistry (BA) Biochemistry Major Requirements (61 Credits) For students declaring Fall 2022 and after CHEM 1045R, 1046R, 1047L, General Chemistry - Lecture and Lab, 8 Credits BIOL 1011R&L, 1012R&L, Principles of Biology- Lecture and Lab, 10 Credits CHEM 1213R, 1214R, 1215L, Organic Chemistry- Lecture and Lab, 8 Credits CHEM 1415R or 1416R, Physical Chemistry I or II, 4 Credits MATH 1412, Calculus I, 4 Credits CHEM 1376R, Principles of Biochemistry - Lecture, 3 Credits CHEM 1377L, Biochemistry Lab - 2 Credits CHEM 1378R, Advanced Biochemistry - Lecture - 3 Credits Introductory Physics: PHYS 1031R&L, 1032R&L, Introductory Physics - Lecture and Lab, 10 Credits Two of the following courses: BIOL 3207C, Cell Biology - Lecture and Lab, 4 Credits BIOL 3230C, Immunology - Lecture and Lab, 4 Credits BIOL 3513C, Genetics- Lecture and Lab, 4 Credits BIOL 3521C, Molecular Biology - Lecture and Lab, 4 Credits CHE 1379C, Chemistry of Metals in Biology - Lecture and Lab, 4 Credits CHE 1372H, Bioinformatics - Lecture and Lab, 4 Credits For current students declaring prior to Fall 2022 may follow the new requirements or the old requirements below. Biochemistry Requirements (PDF) CHEM 1045R, 1046R, 1047L, General Chemistry - Lecture and Lab, 8 Credits BIOL 1011R&L, 1012R&L, Principles of Biology- Lecture and Lab, 10 Credits CHEM 1213R, 1214R, 1215L, Organic Chemistry- Lecture and Lab, 8 Credits CHEM 1415R or 1416R, Physical Chemistry I or II, 4 Credits MATH 1412, 1413, Calculus I, Calculus II, 8 Credits CHEM 1376R&L, Biochemistry - Lecture and lab, 5 Credits The following Physics Sequence: PHYS 1031R&L, 1032R&L, Introductory Physics - Lecture and Lab, 10 Credits Two of the following courses: BIOL 3207C, Cell Biology - Lecture and Lab, 4 Credits BIOL 3230C, Immunology - Lecture and Lab, 4 Credits BIOL 3513C, Genetics- Lecture and Lab, 4 Credits BIOL 3521C, Molecular Biology - Lecture and Lab, 4 Credits CHE 1379C, Chemistry of Metals in Biology - Lecture and Lab, 4 Credits CHE 1372H, Bioinformatics - Lecture and Lab, 4 Credits Chemistry Minor Chemistry Minor (23 Credits) Required Courses (20 credits) CHE 1045R, General Chemistry 1, 3 Credits CHE 1046R, General Chemistry 2, 3 Credits CHE 1047L, General Chemistry Lab, 2 Credits CHE 1213R, Organic Chemistry 1, 3 Credits CHE 1214R, Organic Chemistry 2, 3 Credits CHE 1215L, Organic Chemistry Lab, 2 Credits CHE 1122C/1415, Chemical Analysis/Physical Chemistry 1, 4 Credits Electives (1 required, 3 credits minimum) CHE 1232C, Medicinal Chemistry, 3 Credits CHEM 1233, Synth. & Character, 3 Credits CHE 1375C, Molecular Biochemistry, 4 Credits CH E 1377, Organometallic Chemistry, 3 Credits CHE/BIO 1376R&L, Biochemistry, 5 Credits CHE 1378H, Chemical Biology, 3 Credits CHE 1379C, Metals In Biology, 4 Credits CHE 1415L, Physical Chemistry Lab, 3 Credits CHE 1607, Inorganic & Structural, 3 Credits CHE 1611, Mol. Structure & Dynamics, 3 Credits CHE 1124, Forensic Chemistry, 3 Credits CHE 1415R, Physical Chemistry 1, 4 Credits CHE 1416R, Physical Chemistry 2, 4 Credits CHE 1222H, 3 Credits CHEM 1373C/H Bioinformatics Courses Please see the Schedule of Classes for the current semester’s offerings. The courses regularly offered by the chemistry department are listed below. CHE 1023L Science of Chemistry: Everyday Life (Lab)(1 credit) Focuses on the study of the properties of matter through experimentation. An emphasis is placed on recording careful observations, collecting data, and analysis of results, including graphical analysis and calculations. Designed to cover concepts which complement the lecture topics, not duplicate them. Corequisite: CHE 1023R. CHE 1023R Science of Chemistry: Everyday Life (Lecture) (2 credits) Takes students on a journey from the observations which form the basis of Dalton's atomic theory through the discovery of subatomic particles and atomic structure, leading to trends in bonding. Molecular structures are covered from the simplest hydrogen molecule to DNA, pausing to consider the chemicals encountered in our 'everyday lives.' Corequisite: CHE 1023L. CHE 1024L Science of Chemistry: Global Issues (Lab) (1 credit) Examines contemporary environment issues through experimentation and provides an understanding of basic laboratory skills. Corequisite: CHE 1024R. CHE 1024R Science of Chemistry: Global Issues (Lecture) (2 credits) Examines contemporary environmental issues, such as fossil fuel consumption, global warming, nuclear power, and ozone depletion with an emphasis on problem-solving and an understanding of basic chemical principles. Corequisite: CHE 1024L. CHE 1045H, 1046H Honors: General Chemistry I & II (Lecture & Lab) (5 credits) This honors-level introduction to chemistry offers a rigorous, fast-paced and concept-rich approach that is ideal for students pursuing a major in the sciences or students on a pre-medical, pre-dental, or pre-engineering track. This two course sequence is recommended for chemistry majors and students interested in undergraduate research in chemistry but is also open to all non-science majors who desire a challenging but rewarding introduction to chemistry. Includes laboratory. CHE 1045R, 1046R General Chemistry I & II (3 credits) This two course sequence explores the fundamental concepts of chemistry on both the atomic and macroscopic scales. Topics include atomic structure and stoichiometry; properties of gases, liquids, and solids; thermochemistry; quantum theory and the electronic structure of atoms; the periodic table and periodic properties; chemical bonding and molecular orbital theory; properties of solutions; thermodynamics; acid-base and solubility equilibria; chemical kinetics; electrochemistry; and nuclear chemistry. Corequisite for CHE1046R: CHE1047L CHE 1047L General Chemistry Lab (2 credits) Laboratory experiments are designed and scheduled to complement lecture topics in CHE1045R and 1046R and enhance students understanding of the principles introduced. Skills introduced include the transfer and manipulation of substances, synthesis and purification of inorganic compounds, absorption spectroscopy, titrations, quantitative analysis, and chemical kinetics. Students gain experience in scientific writing through sever lab reports. Corequisite: CHE 1046R. CHE 1122C Chemical Analysis (4 credits) This one-semester course introduces science majors and pre-health students to the principles and practice of analytical chemistry. The course begins with an introduction to analytical chemistry, including the analytical process, sampling, sources of error, statistics, and data interpretation. The course also covers major types of analyses, including wet methods, spectroscopy, chromatography, and potentiometric techniques. Classroom topics, discussions and problem solving exercises are closely coordinated with laboratory analyses. Prerequisite: CHE 1045R&L, 1046R&L. CHE 1215L Organic Chemistry Laboratory (2 credits) Organic Chemistry Laboratory covers the most common basic experimental techniques in organic chemistry. Emphasis is placed on basic techniques in separation, purification, identification and preparation of organic compounds. Students gain experience in scientific writing through several laboratory reports. Prerequisite: CHE 1046R/H & 1047L. Corequisite: CHE 1213R CHE 1213R, 1214R Organic Chemistry I & II (Lecture) (3 credits) Organic chemistry explores the rich chemistry of carbon. Topics include the structure, synthesis, properties, and reaction mechanisms of the main classes of organic compounds, including compounds of biological importance. Prerequisite: CHE 1046R/H and CHE1047L. Corequisite: CHE 1215L CHE 1232C Medicinal Chemistry (3 credits) The course covers the basic chemical and biological concepts underlying medicinal chemistry. The course content includes an overview of drugs and their action, approaches to drug discovery, quantitative structure-activity relationships, drug delivery, pharmacokinetics, and drug metabolism. Laboratory classes include the modification of a drug's chemical structure with both chemical and biological characterization of the product, determination of acidity and lipophilic/lipophobic drug character, synthesis of a combinatorial drug library, and an antimicrobial bioassay. Prerequisite: CHE 1046R/H and CHE1047L. Prerequisite or corequisite: CHE 1213R & 1215L. CHE 1233C Synthesis and Characterization of Organic and Inorganic Compounds (4 credits) Advanced laboratory techniques; purification and characterization of compounds by physical and chemical methods including NMR spectrometry, UV-VIS and FTIR spectrophotometry, gas and high-performance liquid chromatography and mass spectrometry. Prerequisite: CHE 1214R&1215L. CHE 1372C/H Bioinformatics (3 credits) Modern Biology is data driven and bioinformatics is the combination of Biology and computing. With the data floods, analysis has become challenging. Bioinformatics has developed powerful tools to study problems that include large scale genetic sequencing and studies to understand how certain genes originate and change during evolution. This course will introduce students to some important tools in Bioinformatics that are necessary for the practice of modern biology and medicine. The course will introduce students to basic web-based tools for searching for similar sequences in proteins and nucleotides, accessing databases for protein structures and genes, visualizing molecular structures, to name a few. The course will also train students to read and interpret primary literature articles, write research reports, and make oral presentations. Prerequisites: CHE1046R/H, BIO1012R&L or 1012C [Crosslisted as BIO1372C/H] CHE 1375R Molecular Biochemistry (4 credits) Molecular biochemistry covers the biological aspects of cellular structure, metabolism, regulation, and replication from a chemist's perspective. The topics will range from the sequence of nucleic acids that give rise to functional proteins to the bioenergetic aspects of oxidative phosphorylation involved in cellular respiration. Particular emphasis will be placed on hot topics in modern biochemistry including protein-ligand interactions, DNA polymerization, and membrane transport. Prerequisite: CHE 1046R/H and CHE1047L, BIO 1011R&L. [Crosslisted as BIO 1375C] CHE 1376R Principles of Biochemistry (3 credits) Structure and function of biological molecules, enzyme kinetics, bioenergetics, metabolism, storage and transmission of genetic information, recombinant DNA technology, and selected topics such as membrane transport, hormone action, and muscle contraction. Prerequisite: BIO 1012R&L, CHE 1213R& CHE1215L. [Crosslisted as BIO 1376R] CHE 1377L Biochemistry Laboratory (2 credits) Illustration of the properties of biochemical substances; design and analysis of experiments. Techniques include chromatography, electrophoresis, differential centrifugation, and various types of enzyme assays, including spectrophotometric and radioactive. Prerequisite or corequisite: CHE 1376R. [Crosslisted as BIO 1376L] CHE 1378 Advanced Biochemistry (3 credits) Students will apply previously learned Biochemistry principles to study metabolic pathways, as well as the synthesis and metabolism of biomolecules. Students should be familiar with the molecular properties of biological macromolecules (nucleic acids, proteins, and carbohydrates) and lipids; understand the relationship between the structure and function of biomolecules; demonstrate knowledge of enzyme catalysis and reactions that make up metabolic pathways. Prerequisite: CHE 1375R Corequisite: CHE1377L CHE 1379H Chemistry of Metals in Biology (Lecture and Lab) (4 credits) This course offers a chemical view of the metals in biological systems. Course content includes introductory coordination chemistry, spectroscopic methods used to study metal ions and metal complexes in biological system, and the catalytic properties of important metallo-proteins. Prerequisite: CHE 1046R/H & CHE1047L. CHE 1415L Physical Chemistry Laboratory (3 credits) Emphasizes the measurements and computations of physical chemistry. Experiments illustrate theoretical principles and provide basic experience with quantitative physical measurements including thermochemistry, chemical equilibria, kinetics, electrochemistry, spectrophotometry and computer interfacing. Applications to biochemical systems. Corequisite or Pre-requisite: CHE 1415R. CHE 1415R, 1416R Physical Chemistry I & II (Lecture) (4 credits) Physical chemistry explores the underlying physical and mathematical relationships that interconnect a diverse range of chemical concepts. The first semester considers the fundamentals of chemical thermodynamics, thermochemistry, chemical equilibria, phases of matter, aqueous solutions, electrochemistry, and the kinetic molecular theory of gases. The second semester explores the quantum mechanical nature of atoms and molecules, solutions to the Schrodinger equation, vibrational, rotational and electronic spectroscopies, the electronic structure of multi-electron atoms and molecules and chemical bonding. Prerequisite: CHE 1046R/H &CHE1047L, MAT 1412/1413. Prerequisite or corequisite: PHY 1031/1032R&L or 1041/1042R&L. CHE 1607 Inorganic and Structural Chemistry (3 credits) This course introduces students to an advanced physical understanding of inorganic chemistry. Students will learn to use the theories of chemical bonding to predict the electronic structures of compounds and how those electronic structures then give rise to observed chemical and physical properties. Specifically, the transition between two-electron energies of weak ligand fields and one-electron energies of strong ligand fields will be highlighted to describe phenomena found in nature. Students who finish the course will understand how symmetry may be used to predict molecular properties, which metal complexes will be more stable than others, and how interactions between light, electrons, and nuclei are responsible for much of what we see in everyday life. Prerequisite: CHE 1046R/H & 1047L, MAT 1413. CHE 1609H Bioinorganic Chemistry (3 credits) Elucidates key inorganic chemistry concepts, including chemical bonding, structure, reactions and characterization methods and their applications in biology and medicine. Bioinorganic chemistry is a rapidly expanding interdisciplinary field. Topics include metalloenzymes, iron transport proteins, biomineralization in bones and shells and chemotherapeutic agents. Prerequisite: CHE 1046R/H & 1047L CHE 1611, 1611H Molecular Structure, and Dynamics (3 credits) This course introduces the structure of molecules through molecular modelling and covers the theoretical prediction of the electronic structure and properties of molecules, the manipulation and visualtion of structures, simulation techniques such as molecular dynamics and Monte Carlo methods, and familiarity with commonly used software packages. This course incorporates a workship based approach within an integrated lecture and computer laboratory format. Prerequisite: CHE 1046R/H & 1047L CHE 1930 Selected Topics (2 credits) Seminar in current problems and literature in chemistry for seniors majoring in chemistry and selected juniors. Assigned topics, regular conferences and a report. Prerequisite: By permission of the instructor. CHE 1936 Introduction to Chemical Research (0.5 credits) This course offers students an early exposure to the current research interests of our ¶¶Òõapp as well as information about modern chemistry careers. This course is ideal for students with minimal background in chemistry or undergraduate research and serves to help students (particularly future majors) choose a research mentor during their undergraduate years. Students will have the opportunity to visit ¶¶Òõapp research laboratories and obtain first-hand experience of chemical research. Prerequisite or corequisite: CHE 1046R/H & 1047L CHE 1937, 1938 Seminar in Advanced Chemistry (1 credit) Seminar meeting two hours every two weeks. Topics in all fields of chemistry. Prerequisite or Corequisite: CHE 1213R & 1215L or by permission of the instructor. CHE 4911 Research in Chemistry (1-3 credits) Department approval required; final approval required from Academic Standards in order to proceed. Laboratory fee on an individual basis. Faculty and Staff James Camara Clinical Associate Professor PhD, Columbia University, 2009 BS, University of Rochester, 2004 Research Interests: Catalysis, Inorganic & Bioinorganic Chemistry, Organometallic Chemistry Full Faculty Profile Irina Catrina Clinical Assistant Professor Ph.D. Utah State University B. Eng. University "Politehnica" of Bucharest Research Interests: Organic Chemistry, Biochemistry, RNA Structure and Folding,Regulatory RNAs, Advanced Light Microscopy Full Faculty Profile Jinzi Deng Clinical Assistant Professor PhD, University of Connecticut BS, East Chine University of Science and Technology Research Interests: Chemical Engineering, Microfluidics Full Faculty Profile Cecily Dobin Instructor in Chemistry, Emerita Ran Drori Assistant Professor PhD The Hebrew University Research Interests: Biochemistry, Antifreeze proteins, Microscopy Full Faculty Profile Donald Estes Senior Laboratory Instructional Specialist PhD, University of Illinois at Urbana-Champaign, 1982 BS, Wayne State University, 1977 Research Interests: Chemical Education, Biophysical Chemistry Full Faculty Profile Jacob Herman Senior Laboratory Technician Jianfeng Jiang Associate Professor of Chemistry PhD, State University of New ¶¶Òõapp at Stony Brook BS, Peking University Research Interests: Inorganic Chemistry, Bioinorganic Chemistry Anna Jackowski anna.jackowski@yu.edu Chaya Rapp Associate Professor or Chemistry, Co-Chair PhD, Columbia University MA, Columbia University BA, Columbia University Research Interests: Computational Chemistry, Protein Structure and Function Full Faculty Profile Nelson Ruiz Laboratory Specialist Raji Viswanathan Professor of Chemistry, Co-Chair PhD, Oklahoma State University MS, BSC, Madras University Research Interests: Computational Chemistry, Computational Biology, Protein-Protein Interactions Full Faculty Profile Facilities and Equipment Wilf Campus Instrumentation Nicolet 380 FT-IR spectrometer Nicolet iS10 FT-IR spectrometer Biotage Initiator microwave reactor Biotage Isolera One chromatography station Glass Contours solvent purification system CH Instruments 630D electrochemical analyzer MBraun Unilab 2000 double glovebox Mettler-Toledo XS105 analytical balance Cary 300 dual beam UV-VIS spectrometer Agilent 7820A GC with autosampler and FID detector HP 5890 CG with FID detector Shimadzu 2010/QP2010 GC-MS Waters 1525/2487 HPLC system Buchi R200 rotovaps Perkin Elmer AAnalyst 300 atomic absorption spectrometer PTI 2798 fluorimeter Hettich Rotana 460R refrigerated centrifuge Various analytical balances and Schlenk lines Beren Campus Instrumentation Perkin Elmer DSC 4000 differential scanning calorimeter Perkin Elmer Enspire multimore plate reader (3) Erlab portable fume hoods Anasazi EFT-60 NMR spectrometer SI Analytics Trito Line automatic titrator LabSynergy automatic titrator Rudolph Autopol II polarimiter Perkin Elmer LS50B luminescence spectrometer Perkin Elmer Lambda 2 UV-Vis spectrometer with Peltier controller Perkin Elmer Lambda 40 UV-Vis spectrometer Perkin Elmer Spectrum 100 infrared spectrometer Eppendorf 5414 centrifuge Sorval RC5C+ centrifuge rotavaps and various analytical balances Resources Internships Information and applications for undergraduate research programs may be found in the following sites: YU Career Center Careers American Chemical Society's Biochemical Society's Royal Society of Chemistry's Sloan Career Cornerstone Center's US Bureau of Labor Statistics
